Just finished upgrading my Synology DS216+II to 8GB of DDR3L (low voltage) Kingston memory, from the stock 1GB RAM.. This will hopefully improve performance and caching, especially since I can turn off memory compression now and perhaps help with Plex Hardware Transcoding.
The disassembly was pretty straight-forward. After removing the drives and sliding the top cover backward (fastened to the frame by 2 plastic pegs inside) simply remove the 7 screws holding the chassis in place.
Then gently pry the board out to reveal the DIMM slot at the bottom:
…put it back together, and viola!